前药
化学
细胞毒性T细胞
受体
酶
癌症研究
药理学
生物化学
生物
体外
作者
Thibaut Legigan,Jonathan Clarhaut,Isabelle Tranoy‐Opalinski,Arnaud Monvoisin,Brigitte Renoux,Mikaël Thomas,Alain Le Pape,Stéphanie Lerondel,Sébastien Papot
标识
DOI:10.1002/anie.201204935
摘要
Massive attack: Galactoside prodrugs have been designed that can be selectively activated by lysosomal β-galactosidase located inside cancer cells expressing a specific tumor-associated receptor. This efficient enzymatic process triggers a potent cytotoxic effect, releasing the potent antimitotic agent MMAE and allowing the destruction of both receptor-positive and surrounding receptor-negative tumor cells.
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