Cmin公司
接收机工作特性
医学
利奈唑啉
内科学
逻辑回归
尤登J统计
回顾性队列研究
曲线下面积
病危
最大值
药代动力学
万古霉素
生物
细菌
遗传学
金黄色葡萄球菌
作者
Haiyan Dong,Jiao Xie,L.-H. Chen,T.-T. Wang,Yingren Zhao,Yalin Dong
标识
DOI:10.1007/s10096-013-2041-3
摘要
To investigate the risk factors associated with the development of thrombocytopenia, and define the thresholds of efficacy and safety in critically ill patients who received linezolid therapy. A retrospective study was performed in critically ill patients treated with linezolid. Risk factors associated with thrombocytopenia were identified via medical records and trough levels (Cmin) measured during linezolid treatment. By establishing a logistic model, the risks were predicted by the receiver operating characteristic (ROC) curve and the thresholds of efficacy and safety were identified in the patients. Logistic analysis showed that, weight (OR = 0.906; 95 % CI, 0.839–0.978; P = 0.011), baseline platelet count (OR = 0.989; 95 % CI, 0.977–1.000; P = 0.049), Cmin (OR = 1.545; 95 % CI, 1.203–1.983; P = 0.001), and APACHE II score (OR = 1.130; 95 % CI, 1.003–1.273; P = 0.044) were significant factors for linezolid-associated thrombocytopenia. The area under the ROC curve of the combined predictor was larger based on the above factors. When the Youden index was the maximum, the best optimal cut-off point was 205.6 on the ROC curve; when Cmin ≥ 2 mg/L, the probability of bacterial eradication was more than 80 %; when Cmin ≥ 6.3 mg/L, the probability of thrombocytopenia was more than 50 %. In clinical practice, when the calculating results of the combined predictor ≤205.6, the risk of the development of thrombocytopenia may be higher. Furthermore, maintenance of Cmin between 2 and 6.3 mg/L over time may be helpful in retaining appropriate efficacy and reducing the associated thrombocytopenia.
科研通智能强力驱动
Strongly Powered by AbleSci AI