Objective To observe the clinical effect of Sulfasalazine combined with Changweikang tablets in treatment of ulcerative colitis. Methods 90 cases with ulcerative colitis were randomly divided into two groups,the control group was given sulfasalazine,the treatment group was given sulfasalazine combined with Changweikang tablets,the curative effect were compared after treating for 1 month. Results The total effective rate of treatment group was significantly better than the control group( P 0. 01). Conclusion Sulfasalazine combined with Changweikang tablets in treatment of ulcerative colitis have obviously better effect than simple using Sulfasalazine.