Risk analysis of hepatocellular carcinoma in people with hepatitis B virus infection

OBJECTIVE: To study the relationship between hepatocellular carcinoma and hepatitis B virus by reviewing the level of serum markers of hepatitis B virus in hepatocellular carcinoma cases and other cases without liver diseases.METHODS:The cases of hepatocellular carcinoma(224) and non-liver diseases(280) were sampled hospitalized in the First Affiliated Hospital of China Medical University.Then a case-control study was performed on serum markers of HBV and the history of hepatitis B,cirrhosis and so on of all the cases.RESULTS: The total infection rate of HBV in the heatocellular carcinoma cases was 68.22%(146/214) with 65.42%(140/214) of HBsAg and 30.84%(66/214) of anti-HBe,and 7.63%(20/262) in the non-liver disease cases.There was a significant difference(χ2=200.1,P0.000 1) on the total infection of HBV between the hepatocellular carcinoma cases and the controls,and the relative risk calculated was 27.4(95%CI 16.0-46.9).CONCLUSION: HBV is a major risk factor for hepatocellular carcinoma and PHC screening for people with HBV infection plays an important role in the PHC early diagnosis and improving therapeutic effect.