Experimental study on the therapeutic effect of Supplemented Four Gentlemen Decoction on allergic rhinitis among rats

Objective To observe the therapeutic effect of Supplemented Four Gentlemen Decoction (SFGD) on allergic rhinitis among rats based on an experimental study. Methods The model preparing principles combined disease modeling with pattern establishing in the same animals were utilized in this study to prepare experimental nasal allergy among rats with ovalbumin, supplemented by Minor Qi-Infusing Decoction taken via intragastric administration in the terms of precipitating method to prepare the pattern of Spleen deficiency simultaneously among them in experimental group (EG). When the model was established well, these rats in EG were given SFGD to treat the lesion. During the whole experimental period, observed comparatively were the variations in sensitivity of animals in different groups to the same kind of allergen, the changes in allergic symptoms of rats in EG following the treatment with SFGD, and the distributing differences of eosinophile granulocyte (EOS) and mast calls (MC) in nasal secretion and epithelia among various groups. Results When compared with that of controlling groups, the sensitivity of animals in EG to the same kind of allergen was significantly increased, while the allergic symptoms were markedly relieved as well as the number and infiltrating density of EOS and MC in nasal secretion and epithelia were both obviously improved among them (P0.01). Conclusions The individuals with the pattern of Spleen deficiency hold a significantly elevated degree of sensitivity to the same kind of allergen, as compared with that of healthy ones, so that they are in a much more affectability to nasal allergy. Then, the treating principle of Spleen-fortifying Qi-boosting will be very effective for the treatment of them with such a condition.