The research progress of morphogen-regulated cell morphogenesis during Drosophlia wing disc development

Drosophila wing disc is a good model system to study the cell morphogenesis. During the development of the larval wing discs,morphogens secrete from high concentration region to low concentration receiving cells to form a dynamic gradient. Morphogen signaling pathways regulate the cell morphogenesis,survival,proliferation,and differentiation. Up to date,three morphogens have been identified in the wing discs,which are Hedgehog( Hh),Decapentaplegic( Dpp),and Wingless( Wg). In this review,we summarize the functions and discuss the molecular mechanisms of these three morphogens in cell morphogenesis.