重性抑郁障碍
端粒
萧条(经济学)
心理学
细胞老化
不利影响
临床心理学
医学
精神科
内科学
认知
遗传学
基因
生物
宏观经济学
经济
作者
Linn K. Kuehl,Karin de Punder,C.E. Deuter,D.S. Martens,Christine Heim,Christian Otte,Katja Wingenfeld,Sonja Entringer
标识
DOI:10.1016/j.psyneuen.2022.105762
摘要
Major depressive disorder (MDD) and adverse childhood experiences (ACE) are associated with poor physical and mental health in adulthood. One underlying mechanism might be accelerated cellular aging. For example, both conditions, MDD and ACE, have been related to a biological marker of cellular aging, accelerated shortening of telomere length (TL). Since MDD and ACE are confounded in many studies, we aimed with the current study to further disentangle the effects of MDD and ACE on TL using a full-factorial design including four carefully diagnosed groups of healthy participants and MDD patients with and without ACE (total N = 90, all without use of antidepressants). As dependent variable, TL was assessed in leukocytes. We found no group differences based on MDD and ACE exposure in TL. While TL was negatively associated with age and male sex, TL was not associated with any measure of severity of MDD, ACE or current stress. One possible explanation for our null result may be the comparatively good physical health status of our sample. Future research is needed to elucidate the relation of TL, MDD and ACE, taking potential effect modification by medication intake and physical health status into account.
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