过氧化氢
呼出的空气
呼出气冷凝液
化学
光谱学
环境化学
核磁共振波谱
气体分析呼吸
色谱法
有机化学
毒理
物理
量子力学
哮喘
生物
医学
内科学
作者
Tayeb Kakeshpour,Belhu B. Metaferia,Richard N. Zare,Ad Bax
标识
DOI:10.1073/pnas.2121542119
摘要
Hydrogen peroxide (H2O2) plays a key role in environmental chemistry, biology, and medicine. H2O2 concentrations typically are 6 to 10 orders of magnitude lower than that of water, making its quantitative detection challenging. We demonstrate that optimized NMR spectroscopy allows direct, interference-free, quantitative measurements of H2O2 down to submicromolar levels in a wide range of fluids, ranging from exhaled breath and air condensate to rain, blood, urine, and saliva. NMR measurements confirm the previously reported spontaneous generation of H2O2 in microdroplets that form when condensing water vapor on a hydrophobic surface, which can interfere with atmospheric H2O2 measurements. Its antimicrobial activity and strong seasonal variation speculatively could be linked to the seasonality of respiratory viral diseases.
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