泊马度胺
医学
中止
肺纤维化
肺毒性
毒性
内科学
多发性骨髓瘤
沙利度胺
肺
作者
Snežana Gajić,Elliott C. Callahan,James K. Brown,Brett M. Elicker,Brett Ley,Paul D. Blanc
出处
期刊:International Journal of Tuberculosis and Lung Disease
[International Union Against Tuberculosis and Lung Disease]
日期:2018-11-01
卷期号:22 (11): 1383-1386
被引量:5
标识
DOI:10.5588/ijtld.18.0244
摘要
Pomalidomide, previously used to treat multiple myeloma, has been reported to cause acute pulmonary toxicity that improves with drug discontinuation. We present a case of delayed pneumonitis with persistent fibrosis associated with pomalidomide. A 61-year-old male treated with pomalidomide and corticosteroids presented with acute on chronic dyspnea, profound hypoxemia, and ground glass opacities on computerized tomographic imaging. Corticosteroid taper and discontinuation of pomalidomide resulted in clinical improvement, but with substantial residual pulmonary fibrosis. Given the temporal improvement, but not resolution, following discontinuation of an agent with an established propensity for lung injury, we attribute this presentation to pomalidomide toxicity.
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