细胞凋亡
活性氧
流式细胞术
细胞内
细胞毒性
比吸收率
生物物理学
化学
医学
癌症研究
生物
体外
细胞生物学
免疫学
生物化学
电信
计算机科学
天线(收音机)
作者
Hongmei Zhou,Guofu Dong,Wen Zheng,Shuiming Wang,Lifeng Wang,Wei Zhi,Changzhen Wang
标识
DOI:10.1080/15368378.2018.1550787
摘要
To investigate the potential cytotoxicity of radiofrequency (RF) radiation on central nervous system, rat pheochromocytoma (PC12) cells were exposed to 2.856 GHz RF radiation at a specific absorption rate (SAR) of 4 W/kg for 8 h a day for 2 days in 35 mm Petri dishes. During exposure, the real-time variation of the culture medium temperature was monitored in the first hour. Reactive oxygen species (ROS) production, intracellular Ca2+ concentration, and cell apoptosis rate were assessed immediately after exposure by flow cytometry. The results showed that the medium temperature raised about 0.93 °C, but no significant changes were observed in apoptosis, ROS levels or intracellular Ca2+ concentration after treatment. Although several studies suggested that RF radiation does indeed cause neurological effects, this study presented inconsistent results, indicating that 2.856 GHz RF radiation exposure at a SAR of 4 W/kg does not have a dramatic impact on PC12 cells, and suggests the need for further investigation on the key cellular endpoints of other nerve cells after exposure to RF radiation.
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