化学
离子迁移光谱法
高效液相色谱法
电喷雾
电喷雾电离
色谱法
漂移管,漂移管
炸薯条
质谱法
等压法
联轴节(管道)
表征(材料科学)
液相色谱-质谱法中的离子抑制
分析化学(期刊)
串联质谱法
离子
纳米技术
计算机科学
工程类
有机化学
物理
热力学
材料科学
机械工程
电信
作者
Sebastian K. Piendl,Christian‐Robert Raddatz,Nora T. Hartner,Christian Thoben,Rico Warias,Stefan Zimmermann,Detlev Belder
标识
DOI:10.1021/acs.analchem.9b00302
摘要
The online hyphenation of chip-based high-performance liquid chromatography (chip-HPLC) with ion mobility spectrometry (IMS) via fully integrated electrospray emitters is introduced. A custom-built drift tube IMS with shifted potentials was developed in order to keep the IMS orifice electrically grounded, allowing for a robust coupling with chip-HPLC. Proof-of-concept studies with the newly developed analytical setup revealed the suitability of IMS as a promising and powerful detection concept for chip-based separation techniques. Comparison of IMS with fluorescence detection and electrospray ionization-mass spectrometry (ESI-MS) allowed a more detailed characterization of the IMS as a new detection method for chip-HPLC. Moreover, the analysis of a mixture consisting of three isobaric antidepressants demonstrated the performance of chip-HPLC/IMS as a miniaturized two-dimensional separation technique.
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