烷基
催化作用
化学
过渡金属
基质(水族馆)
组合化学
金属
计算化学
有机化学
海洋学
地质学
作者
Roman G. Belli,Victoria Tafuri,Courtney C. Roberts
标识
DOI:10.1021/acscatal.2c02785
摘要
Alkyl–alkyl cross-coupling is a powerful C–C bond-forming transformation typically catalyzed by late transition metals. Herein, we report a mechanistic investigation into an early transition metal-catalyzed variant of this reaction. Through this mechanistic understanding, an ideal Y catalyst was determined through tuning of the metal in order to optimize the oxidation potential, which governs the rate-limiting step in this reaction. A wide substrate scope is revealed that includes a variety of functional groups as well as less activated substrates.
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