光动力疗法
光敏剂
线粒体
赫拉
缺氧(环境)
化学
溶酶体
肿瘤缺氧
细胞内
活性氧
猝灭(荧光)
生物物理学
氧气
细胞器
癌症研究
生物化学
光化学
荧光
医学
生物
内科学
细胞
酶
物理
有机化学
放射治疗
量子力学
作者
Wen Lv,Zhang Zhang,Kenneth Yin Zhang,Huiran Yang,Shujuan Liu,Aqiang Xu,Song Guo,Qiang Zhao,Wei Huang
标识
DOI:10.1002/ange.201604130
摘要
Abstract Organelle‐targeted photosensitizers have been reported to be effective photodynamic therapy (PDT) agents. In this work, we designed and synthesized two iridium(III) complexes that specifically stain the mitochondria and lysosomes of living cells, respectively. Both complexes exhibited long‐lived phosphorescence, which is sensitive to oxygen quenching. The photocytotoxicity of the complexes was evaluated under normoxic and hypoxic conditions. The results showed that HeLa cells treated with the mitochondria‐targeted complex maintained a slower respiration rate, leading to a higher intracellular oxygen level under hypoxia. As a result, this complex exhibited an improved PDT effect compared to the lysosome‐targeted complex, especially under hypoxia conditions, suggestive of a higher practicable potential of mitochondria‐targeted PDT agents in cancer therapy.
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