坏死性下垂
神经科学
程序性细胞死亡
神经炎症
疾病
阿尔茨海默病
发病机制
生物
细胞凋亡
医学
病理
免疫学
生物化学
作者
Aman Mangalmurti,John R. Lukens
标识
DOI:10.1016/j.conb.2022.102575
摘要
Despite the long-standing observation of vast neuronal loss in Alzheimer's disease (AD) our understanding of how and when neurons are eliminated is incomplete. While previous investigation has focused on apoptosis, several novel forms of cell death (i.e. necroptosis, parthanatos, ferroptosis, cuproptosis) have emerged that require further investigation. This review aims to collect evidence for different modes of neuronal cell death in AD and to also discuss how these different forms of cell death may impact the neuroinflammatory environment that prevails in the AD brain. Improved understanding of how neurons die may help to delineate disease pathogenesis, provide insights toward treatment, and aid in the development of improved animal models of AD.
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