餐后
内分泌学
内科学
激素
胃抑制多肽
受体
糖尿病
2型糖尿病
生物
胃肠激素
小肠
医学
化学
肽类激素
胰高血糖素
作者
Nunzio Guccio,Fiona M. Gribble,Frank Reimann
标识
DOI:10.1146/annurev-nutr-062320-113625
摘要
Glucose-dependent insulinotropic polypeptide (GIP) is released from the upper small intestine in response to food intake and contributes to the postprandial control of nutrient disposition, including of sugars and fats. Long neglected as a potential therapeutic target, the GIPR axis has received increasing interest recently, with the emerging data demonstrating the metabolically favorable outcomes of adding GIPR agonism to GLP-1 receptor agonists in people with type 2 diabetes and obesity. This review examines the physiology of the GIP axis, from the mechanisms underlying GIP secretion from the intestine to its action on target tissues and therapeutic development.
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