大肠杆菌
阳离子聚合
咔唑
金黄色葡萄球菌
化学
抗菌剂
紫外可见光谱
光谱学
立体化学
组合化学
光化学
生物
生物化学
物理
有机化学
细菌
基因
遗传学
量子力学
作者
Yingjie Niu,Lin Wang,Yingxin Guo,Weihua Zhu,Rodah C. Soy,Balaji Babu,John Mack,Tebello Nyokong,Haijun Xu,Ling Xu
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:51 (27): 10543-10551
被引量:4
摘要
Two A2B type H3corroles and two GaIIItriarylcorroles with carbazole substitutions at 10-positions were synthesized and characterized. An analysis of structure-property relationships of the corroles has been carried out by investigating the optical spectroscopy of the dyes to trends predicted in DFT and TD-DFT calculations. Interestingly, the photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT) activity properties of the GaIIItriarylcorroles were determined against the MCF-7 breast cancer line, and Staphyloccocus aureus (S. aureus) and Escherichia coli (E. coli), respectively. The cationic G-2Q species exhibited the most favorable properties with an IC50 value of 7.8 μM against MCF-7 cells, and Log reduction values of 7.78 and 3.26 against planktonic S. aureus and E. coli at 0.5 and 10 μM, respectively.
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