碳二亚胺
纳米纤维素
抗菌活性
超声
化学
共价键
极限抗拉强度
核化学
伤口愈合
高分子化学
细菌生长
细菌
材料科学
有机化学
色谱法
外科
纤维素
复合材料
医学
生物
遗传学
作者
Mina Shahriari‐Khalaji,Geli Li,Lu Liu,Mamoona Sattar,Lin Chen,Chunyan Zhong,Feng Hong
标识
DOI:10.1016/j.carbpol.2022.119266
摘要
Oxidized bacterial nanocellulose (O-BNC) is a favorable material to subdue bacterial infection because of the carboxylate content that not only has a weak antibacterial activity but also is capable of bonding electrostatically to polycationic antibacterial agents. In this study, the 2,2,6,6-Tetramethylpiperidinyloxy radical (TEMPO)-mediated oxidation of BNC was optimized to achieve high carboxylate content while retaining an acceptable tensile profile. To develop an O-BNC-based functional wound dressing, ε-poly-l-lysine (PLL) was then covalently bonded with O-BNC via 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) reaction after homogeneous distribution by ultrasonication. The antibacterial activity of the obtained wound dressing was significantly higher (p < 0.05), and no toxicity was observed. The infected full-thickness wounds of rats were healed faster (p < 0.05) covered by the dressing due to less inflammation, faster blood vessel proliferation, and epidermal layer formation. The material is an effective and promising functional dressing for the treatment of infected wounds.
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