Oxidative Aminocarbonylation of Terminal Alkynes for the Synthesis of Alk‐2‐ynamides by Using Palladium‐on‐Carbon as Efficient, Heterogeneous, Phosphine‐Free, and Reusable Catalyst

Abstract Palladium‐on‐carbon (Pd/C)‐catalyzed oxidative aminocarbonylations of alk‐1‐ynes with secondary amines provide the corresponding alk‐2‐ynamides in a good to excellent yields. This new methodology is applicable for the synthesis of a wide range of biologically active alk‐2‐ynamide derivatives. The developed protocol avoids the use of phosphine ligands, with an additional advantage of palladium catalyst recovery and reuse for up to four consecutive cycles.