Monitoring of Thoracic Aortic Aneurysm in Blood by Fluorescence Spectroscopy

Components of the blood plasma and serum represent a mixture of various endogenous substances with fluorescence properties. The aim of this work was a detection of pathological changes in blood of patients with thoracic aortic aneurysm by fluorescence spectroscopy and atomic force microscopy. The resulting autofluorescence of fluorophores in blood of patients with thoracic aortic aneurysm decreased in comparison with healthy subjects. The structure of the thoracic aorta was changed during the thoracic aortic aneurysm, what was manifested as the structural modifications in blood of patients observed by using atomic force microscopy. The fluorescence analysis and atomic force microscopy present new experimental ways in the study of the thoracic aortic aneurysm.