Enhancing food system protection: synergistic action of engineered endolysin LYSMP and berberine hydrochloride against Streptococcus suis on pork

CFU/g without affecting sensory quality. Safety assessments showed a 5 % decrease in the hemolysis rate and an 85 % increase in cell viability. In vivo experiments further revealed reduced bacterial load and damage in tissues. The strategy proposed herein is an efficient and safe solution for bio-preservation and a multi-target therapeutic option against resistant infections. Future work will focus on optimizing its scalability for industrial application.