化学
双功能
试剂
组合化学
可见光谱
有机化学
催化作用
光电子学
物理
作者
Jie Liu,Haowen Jiang,Xiu‐Qin Hu,Peng‐Fei Xu,Peng‐Fei Xu
标识
DOI:10.1021/acs.orglett.4c01186
摘要
Considering the ubiquitous presence of pyridine moieties in pharmaceutical compounds, it holds immense value to develop practical and straightforward methodologies for accessing heterocyclic aromatic hydrocarbons. In recent years, N-alkoxypyridinium salts have emerged as convenient radical precursors, enabling the generation of the corresponding alkoxy radicals and pyridine through single-electron transfer. Herein, we present the first report on visible-light-mediated intermolecular alkoxypyridylation of alkenes employing N-alkoxylpyridinium salts as bifunctional reagents with an exceptionally low catalyst loading (0.5 mol %).
科研通智能强力驱动
Strongly Powered by AbleSci AI