褪黑素
活动记录
正视
昼夜节律
医学
多导睡眠图
屈光度
傍晚
听力学
心理学
折射误差
内科学
内分泌学
眼科
视力
呼吸暂停
物理
天文
作者
Ranjay Chakraborty,Chris Seby,Hannah Scott,Victoria Tang,Eva Kemps,Nicola Anstice,Emilia Juers,Nicole Lovato,Deepa Taranath,Richard Mills,Leon Lack
出处
期刊:Sleep
[Oxford University Press]
日期:2023-10-12
卷期号:47 (1)
被引量:17
标识
DOI:10.1093/sleep/zsad265
摘要
Abstract Study Objectives This study investigated the differences in melatonin circadian timing and output, sleep characteristics, and cognitive function in myopic and non-myopic (or emmetropic) children, aged 8–15 years. Methods Twenty-six myopes (refractive error [mean ± standard error mean] −2.06 ± 0.23 diopters) and 19 emmetropes (−0.06 ± 0.04 diopters), aged 11.74 ± 2.31 years were recruited. Circadian timing was assessed using salivary dim-light melatonin onset (DLMO), collected half-hourly for 7 hours, beginning 5 hours before and finishing 2 hours after individual average sleep onset in a sleep laboratory. Nocturnal melatonin output was assessed via aMT6s levels from urine voids collected from 05:30 pm to 8:00 am the following morning. Actigraphy-derived objective sleep timing were acquired for a week prior to the sleep laboratory visit. Cognitive assessments of sustained attention (using psychomotor vigilance task [PVT]) and working memory (using digit spans) were performed on the night of sleep laboratory. Results Myopic children (9:07 pm ± 14 minutes) exhibited a DLMO phase-delay of 1 hour 8 minutes compared to emmetropes (7:59 pm ± 13 minutes), p = 0.002. aMT6s melatonin levels were significantly lower among myopes (18.70 ± 2.38) than emmetropes (32.35 ± 6.93, p = 0.001). Myopes also exhibited significantly delayed sleep onset, delayed wake-up time, poor and reduced sleep, and more evening-type diurnal preference than emmetropes (all p < 0.05). Finally, myopes showed a slower reaction time in the PVT (p < 0.05), but not digit span tasks at night. Conclusions These findings suggest a potential association between circadian rhythm dysfunction and myopia in children.
科研通智能强力驱动
Strongly Powered by AbleSci AI