微生物群
肠道微生物群
肠道微生物群
生物
粪便
遗产管理(遗嘱认证法)
生理学
医学
微生物学
生物信息学
政治学
法学
作者
Sandra Carapeto,Eva Cunha,Isa Serrano,Pedro B. Pascoal,Marcelo Pereira,Raquel Abreu,Santana Neto,Beatriz Antunes,Ricardo Dias,Luís Tavares,Manuela Oliveira
出处
期刊:Genes
[MDPI AG]
日期:2023-08-25
卷期号:14 (9): 1676-1676
被引量:1
标识
DOI:10.3390/genes14091676
摘要
Faecal Microbiota Transplantation (FMT) is a promising strategy for modulating the gut microbiome. We aimed to assess the effect of the oral administration of capsules containing lyophilised faeces on dogs with diarrhoea for 2 months as well as evaluate their long-term influence on animals' faecal consistency and intestinal microbiome. This pilot study included five dogs: two used as controls and three with diarrhoea. Animals were evaluated for four months by performing a monthly faecal samples collection and physical examination, which included faecal consistency determination using the Bristol scale. The total number of viable bacteria present in the capsules was quantified and their bacterial composition was determined by 16S rRNA gene sequencing, which was also applied to the faecal samples. During the assay, no side effects were reported. Animals' faecal consistency improved and, after ending capsules administration, Bristol scale values remained stable in two of the three animals. The animals' microbiome gradually changed toward a composition associated with a balanced microbiota. After FMT, a slight shift was observed in its composition, but the capsules' influence remained evident during the 4-month period. Capsules administration seems to have a positive effect on the microbiota modulation; however, studies with more animals should be performed to confirm our observations.
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