神经炎症
神经科学
疾病
神经学
神经退行性变
痴呆
发病机制
嘌呤能受体
阿尔茨海默病
医学
氧化应激
病态的
受体
生物信息学
心理学
生物
免疫学
病理
内科学
作者
Qiang Huang,Jun Ying,Wen-Kai Yu,Yanlei Dong,Hui Xiong,Yiping Zhang,Jie Liu,Xifeng Wang,Fuzhou Hua
标识
DOI:10.1007/s12035-023-03699-9
摘要
Alzheimer's disease (AD) is a major cause of age-related dementia, which is becoming a global health crisis. However, the pathogenesis and etiology of AD are still not fully understood. And there are no valid treatment methods or precise diagnostic tools for AD. There is increasing evidence that P2X7R expression is upregulated in AD and is involved in multiple related pathological processes such as Aβ plaques, neurogenic fiber tangles, oxidative stress, and chronic neuroinflammation. This suggests that P2X7R may be a key player in the development of AD. P2X7R is a member of the ligand-gated purinergic receptor (P2X) family. It has received attention in neuroscience due to its role in a wide range of aging and age-related neurological disorders. In this review, we summarize current information on the roles of P2X7R in AD and suggest potential pharmacological interventions to slow down AD progression.
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