光动力疗法
单线态氧
光毒性
钌
光热治疗
化学
光化学
抗菌剂
生物医学中的光声成像
组合化学
纳米技术
氧气
有机化学
催化作用
材料科学
生物化学
体外
物理
光学
作者
Ng Xiao Ying,Fong Kar Wai,Lik Voon Kiew,Katrina Chung Pooi Yin,Liew Yun Khoon,Nicolas Delsuc,Mohd Zulkefeli,L. Lee
标识
DOI:10.1016/j.jinorgbio.2023.112425
摘要
Photodynamic therapy (PDT) has recently emerged as a potential valuable alternative to treat microbial infections. In PDT, singlet oxygen is generated in the presence of photosensitisers and oxygen under light irradiation of a specific wavelength, causing cytotoxic damage to bacteria. This review highlights different generations of photosensitisers and the common characteristics of ideal photosensitisers. It also focuses on the emergence of ruthenium and more specifically on Ru(II) polypyridyl complexes as metal-based photosensitisers used in antimicrobial photodynamic therapy (aPDT). Their photochemical and photophysical properties as well as structures are discussed while relating them to their phototoxicity. The use of Ru(II) complexes with recent advancements such as nanoformulations, combinatory therapy and photothermal therapy to improve on previous shortcomings of the complexes are outlined. Future perspectives of these complexes used in two-photon PDT, photoacoustic imaging and sonotherapy are also discussed. This review covers the literature published from 2017 to 2023.
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