光动力疗法
光子上转换
体内
癌症治疗
纳米技术
材料科学
磁共振成像
癌症
化学
光电子学
医学
发光
生物
放射科
有机化学
生物技术
内科学
作者
Yilin Liu,Yuan Liang,Pengpeng Lei,Zhen Zhang,Yongming Chen
标识
DOI:10.1002/advs.202203669
摘要
Theranostics, the combination of diagnostics and therapies, has been considered as a promising strategy for clinical cancer treatment. Nonetheless, building a smart theranostic system with multifunction for different on-demand applications still remains elusive. Herein, an easy and user-friendly microemulsion based method is developed to modularly assemble upconversion nanoparticles (UCNPs) and Fe3 O4 nanoparticles together, forming multifunctional UCNPs/Fe3 O4 superparticles with highly integrated functionalities including the 808 nm excitation for real-time NIR-II imaging, magnetic targeting, and the upconversion luminescence upon 980 nm excitation for on-demand photodynamic therapy (PDT). With a magnet placed nearby the tumor, in vivo NIR-II imaging uncovers that superparticles tend to migrate toward the tumor and exhibit intense tumor accumulation, ≈6 folds higher than that without magnetic targeting 2 h after intravenous injection. NIR laser irradiation is then used to trigger PDT, obtaining an outstanding tumor elimination under magnetic tumor targeting, which shows a high potential to be applied in targeted cancer theranostics.
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