Adverse Reactions to Cosmetic Fillers in the Oral and Maxillofacial Region: Clinico‐Pathological, Histochemical, and Immunohistochemical Characterization

An evident macrophage reaction is observed in all aesthetic fillers, frequently associated with giant cell formation. Despite similarities, there are specific features of each material and the host response that assist the correct histopathological diagnosis. Immunohistochemistry for CD68 and Toluidine blue stain are useful in doubtful cases.