微生物群
生物
人类微生物组计划
拟杆菌
厚壁菌
疾病
肠道微生物群
人体微生物群
情感(语言学)
寄主(生物学)
免疫学
遗传学
计算生物学
医学
基因
心理学
16S核糖体RNA
沟通
病理
作者
Maurizio Salvadori,Giuseppina Rosso
出处
期刊:World journal of methodology
[Baishideng Publishing Group Co (World Journal of Methodology)]
日期:2024-03-20
卷期号:14 (1)
标识
DOI:10.5662/wjm.v14.i1.89196
摘要
The Human Microbiome Project, Earth Microbiome Project, and next-generation sequencing have advanced novel genome association, host genetic linkages, and pathogen identification. The microbiome is the sum of the microbes, their genetic information, and their ecological niche. This study will describe how millions of bacteria in the gut affect the human body in health and disease. The gut microbiome changes in relation with age, with an increase in Bacteroidetes and Firmicutes. Host and environmental factors affecting the gut microbiome are diet, drugs, age, smoking, exercise, and host genetics. In addition, changes in the gut microbiome may affect the local gut immune system and systemic immune system. In this study, we discuss how the microbiome may affect the metabolism of healthy subjects or may affect the pathogenesis of metabolism-generating metabolic diseases. Due to the high number of publications on the argument, from a methodologically point of view, we decided to select the best papers published in referred journals in the last 3 years. Then we selected the previously published papers. The major goals of our study were to elucidate which microbiome and by which pathways are related to healthy and disease conditions.
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