肺
医学
灌注
机械通风
呼气末正压
肺容积
充氧
心脏病学
麻醉
内科学
作者
Gabriel Ribeiro,Tilo Winkler,Eduardo Leite Vieira Costa,Nicolas de Prost,Mauro R. Tucci,Marcos F. Vidal Melo
标识
DOI:10.1152/japplphysiol.00028.2023
摘要
Perfusion redistribution does not follow lung density redistribution in the first 16–24 h of systemic endotoxemia and protective tidal volume mechanical ventilation. The same oxygenation-based positive end-expiratory pressure (PEEP)-setting strategy can lead at different endotoxemia levels to different perfusion redistributions, PEEP values, and lung aerations, worsening lung biomechanical conditions. During early acute lung injury, regional perfusion-to-tissue density ratio is associated with increased neutrophilic inflammation, and susceptibility to nondependent capillary occlusion and lung derecruitment, potentially marking and/or driving lung injury.
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