Low-density Pt nanoarray-based hydrogen peroxide sensing platform and its application in trace sarcosine detection

Hydrogen peroxide (H2O2) is an important signaling molecule that regulates many biological processes. It is of great value to realize rapid, accurate, highly sensitive and low-cost H2O2 detection in the immediate detection of trace disease markers. Low-density nanoelectrode arrays have a high signal-to-noise ratio and are advantageous for trace detection. In this paper, low-density Pt nanoelectrode arrays were successfully prepared by a simple method of ion sputtering combined with electrodeposition based on a track-etched polycarbonate membrane template. The arrays had a detection limit as low as 0.03 μM for H2O2 at a constant potential, a sensitivity of 125.9 μA mM−1, and a linear range spanning nearly four orders of magnitude (0.1–655 μM). The developed sarcosine sensors based on these arrays had a very low detection limit (0.08 μM) and wide linear range (0.5–64.5 μM) for the rapid detection of trace amounts of sarcosine in serum. With a wide linear range and low detection limits, this hydrogen peroxide sensing platform has great potential for use in the rapid electrochemical detection of trace substances.