心理学
自闭症
颞上沟
神经质的
脑岛
功能磁共振成像
颞上回
认知心理学
发展心理学
人口
多传感器集成
听力学
自闭症谱系障碍
神经科学
感觉系统
医学
人口学
社会学
作者
Kacie Dunham,Alisa R. Zoltowski,Jacob Feldman,Seth J. Davis,Baxter P. Rogers,Michelle D. Failla,Mark T. Wallace,Carissa J. Cascio,Tiffany G. Woynaroski
出处
期刊:Multisensory Research
[Brill]
日期:2023-01-19
卷期号:36 (3): 263-288
标识
DOI:10.1163/22134808-bja10093
摘要
Autistic youth demonstrate differences in processing multisensory information, particularly in temporal processing of multisensory speech. Extensive research has identified several key brain regions for multisensory speech processing in non-autistic adults, including the superior temporal sulcus (STS) and insula, but it is unclear to what extent these regions are involved in temporal processing of multisensory speech in autistic youth. As a first step in exploring the neural substrates of multisensory temporal processing in this clinical population, we employed functional magnetic resonance imaging (fMRI) with a simultaneity-judgment audiovisual speech task. Eighteen autistic youth and a comparison group of 20 non-autistic youth matched on chronological age, biological sex, and gender participated. Results extend prior findings from studies of non-autistic adults, with non-autistic youth demonstrating responses in several similar regions as previously implicated in adult temporal processing of multisensory speech. Autistic youth demonstrated responses in fewer of the multisensory regions identified in adult studies; responses were limited to visual and motor cortices. Group responses in the middle temporal gyrus significantly interacted with age; younger autistic individuals showed reduced MTG responses whereas older individuals showed comparable MTG responses relative to non-autistic controls. Across groups, responses in the precuneus covaried with task accuracy, and anterior temporal and insula responses covaried with nonverbal IQ. These preliminary findings suggest possible differences in neural mechanisms of audiovisual processing in autistic youth while highlighting the need to consider participant characteristics in future, larger-scale studies exploring the neural basis of multisensory function in autism.
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