生物
原癌基因蛋白质c-kit
受体酪氨酸激酶
突变体
基因座(遗传学)
分子生物学
跨膜蛋白
酪氨酸激酶
基因
细胞生物学
造血
信号转导
遗传学
受体
干细胞因子
干细胞
作者
Karl Nocka,S Majumder,Benoît Chabot,Prabir Ray,Michelle Cervone,Alan Bernstein,Peter Besmer
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:1989-06-01
卷期号:3 (6): 816-826
被引量:483
摘要
The proto-oncogene c-kit, a transmembrane tyrosine protein kinase receptor for an unknown ligand, was shown recently to map to the dominant white spotting locus (W) of the mouse. Mutations at the W locus affect various aspects of hematopoiesis, as well as the proliferation and/or migration of primordial germ cells and melanoblasts during development. Here, we show that c-kit is expressed in tissues known to be affected by W mutations in fetal and adult erythropoietic tissues, mast cells, and neural-crest-derived melanocytes. We demonstrate that the c-kit associated tyrosine-specific protein kinase is functionally impaired in W/WV mast cells, thus providing a molecular basis for understanding the developmental defects that result from these mutations.
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