唾液
腮腺
腮腺导管
高氯酸盐
内分泌学
卡巴胆碱
内科学
唾液腺
化学
分泌物
孵化
锝
体外
导管(解剖学)
生物
闪烁照相术
医学
病理
生物化学
刺激
核化学
作者
Philip C. Fox,Lipa Bodner,Mary R. Bowers,Bruce J. Baum
出处
期刊:Comparative Biochemistry and Physiology Part A: Physiology
[Elsevier]
日期:1986-01-01
卷期号:83 (3): 579-584
被引量:10
标识
DOI:10.1016/0300-9629(86)90149-0
摘要
The ability of acinar cells of the rat parotid gland to transport technetium pertechnetate (99mTcO-4) was examined. After intravenous injection, 99mTcO-4 was rapidly detected in parotid saliva. There was an excellent correlation between saliva and plasma 99mTcO-4 levels. The saliva to plasma ratio was always less than 1, consistent with the inability of rat parotid gland duct cells to concentrate the anion. Output of 99mTcO-4 by the parotid gland closely mimicked fluctuations in parotid saliva flow rate. In vitro, enzymatically dispersed parotid acinar cells accumulated 99mTcO-4 from the incubation medium in a biphasic manner. This uptake was partially blocked by 10(-4) M NaI. Cells which had accumulated 99mTcO-4 showed increased radionuclide efflux after exposure to 10(-5) M carbachol.
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