聚丙烯酸
材料科学
纳米团簇
荧光寿命成像显微镜
荧光
药物输送
阿霉素
纳米颗粒
体内
纳米技术
纳米载体
分子成像
临床前影像学
生物医学工程
化疗
医学
聚合物
复合材料
生物技术
外科
物理
生物
量子力学
作者
Lü Li,Lingyu Zhang,Tingting Wang,Xiaotong Wu,Hong Ren,Chungang Wang,Zhong‐Min Su
出处
期刊:Small
[Wiley]
日期:2015-03-05
卷期号:11 (26): 3162-3173
被引量:65
标识
DOI:10.1002/smll.201403517
摘要
Engineering novel theranostic agents with both imaging and therapeutic functions have profound impact on molecular diagnostics, imaging, and therapeutics. In this paper, we develop for the first time a simple, scalable, and reproducible route to synthesize novel multifunctional spherical Au nanoclusters assemblies encapsulated by a polyacylic acid (PAA)/calcium phosphate (CaP) shell with aggregation enhanced fluorescence property (designated as AuNCs-A@PAA/CaP). Furthermore, the resulting AuNCs-A@PAA/CaP nanoparticles (NPs) possess a high payload of doxorubicin as synergetic pH-sensitive drug delivery vehicles to employ for dual-modal computed tomography (CT) and fluorescence imaging-guided liver cancer chemotherapy in vivo. The results reveal that AuNCs-A@PAA/CaP NPs not only provide excellent bimodal CT and fluorescence contrast imaging but also present efficient tumor ablation under the guidance of CT and fluorescence imaging, to achieve excellent chemotherapeutic efficacy to the hepatocarcinoma cell line (H-22) bearing mice through intravenous injection. Comprehensive blood tests and careful histological examinations reveal no apparent toxicity of AuNCs-A@PAA/CaP NPs. Our work highlights the great promise of AuNCs-A@PAA/CaP NPs for guiding and monitoring the chemotherapeutic process using simultaneous dual-modality CT and fluorescence imaging through a single theranostic agent.
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