HLA alleles and fissured tongue

Summary The aim of this study was to investigate the linkage between HLA and fissured tongue. Sixty‐ nine individuals with fissured tongue and 125 healthy volunteers were typed for HLA‐DRB1*. The results showed increased frequency of HLA‐DRB1*08 ( P < 0.001), HLA‐DRB1*14 ( P < 0.01), HLA‐DRB1*11 ( P < 0.05) and HLA‐DRB1*16 ( P < 0.05), while HLA‐DRB1*03 and HLA‐DRB1*07 frequency was decreased ( P < 0.05).