肾上腺脑白质营养不良
白质
小脑
共济失调
小脑共济失调
脑干
病理
痉挛的
医学
遗传性痉挛性截瘫
解剖
磁共振成像
桥
白质营养不良
神经科学
心理学
生物
内分泌学
内科学
脑瘫
放射科
物理医学与康复
疾病
受体
表型
过氧化物酶体
基因
生物化学
作者
Kuroda S,Asao Hirano,S. Yuasa
摘要
A case of adrenoleukodystrophy was studied morphologically and biochemically. The patient was a 28-year-old man with no family history of adrenoleukodystrophy. His neurologic symptoms were cerebellar ataxia, spastic paraplegia, pseudo-bulbar palsy, and a minimal visual disturbance, with neither adrenal nor hypogonadal symptoms. The morphological and biochemical findings in this case are identical with those in typical adrenoleukodystrophy, but the topographical distribution of the lesions is distinctly different. The changes selectively affect the white matter in the cerebellum and brain stem in contrast to minimal involvement of the occipital white matter.
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