结直肠癌
肿瘤科
内科学
癌症
细胞凋亡
医学
生物
癌症研究
生物信息学
遗传学
作者
Andreas U. Lindner,Manuela Salvucci,Clare Morgan,Naser Monsefi,Alexa J. Resler,Mattia Cremona,Sarah Curry,Sinéad Toomey,Robert O’Byrne,Orna Bacon,Michael Stühler,Lorna Flanagan,Richard H. Wilson,Patrick G. Johnston,Manuel Salto‐Tellez,Sophie Camilleri‐Bröet,Deborah A. McNamara,Elaine W. Kay,Bryan T. Hennessy,Pierre Laurent–Puig
出处
期刊：Gut
[BMJ]
日期：2016-09-23
卷期号：66 (12): 2141-2148
被引量：49
标识
DOI：10.1136/gutjnl-2016-312287
摘要
The mitochondrial apoptosis pathway is controlled by an interaction of multiple BCL-2 family proteins, and plays a key role in tumour progression and therapy responses. We assessed the prognostic potential of an experimentally validated, mathematical model of BCL-2 protein interactions (DR_MOMP) in patients with stage III colorectal cancer (CRC).
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