醛
化学
砜
加合物
炔烃
叠氮化物
组合化学
有机化学
催化作用
作者
William Doherty,Paul Evans
标识
DOI:10.1021/acs.joc.5b02556
摘要
An operationally simple protocol for the synthesis of γ-hydroxy vinyl sulfones has been developed using a proline-based aldehyde aminooxylation, followed by a vinyl sulfone forming Horner–Wadsworth–Emmons olefination. The adducts, formed in high enantiopurity, were subsequently converted to γ-azido vinyl sulfones, and azide–alkyne click chemistry enabled the synthesis of vinyl sulfone-based triazoles as potential nonpeptidic cysteine protease inhibitors.
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