端粒
缺氧(环境)
端粒酶
DNA损伤
生物
细胞生物学
癌症研究
DNA
遗传学
化学
氧气
基因
有机化学
作者
Manjula Miglani,Qadar Pasha,Archana Gupta,Anjali Priyadarshini,Ramendra Pati Pandey,Arpana Vibhuti
标识
DOI:10.1016/j.drudis.2021.07.012
摘要
Cellular exposure to extreme environments leads to the expression of multiple proteins that participate in pathophysiological manifestations. Hypobaric hypoxia at high altitude (HA) generates reactive oxygen species (ROS) that can damage telomeres. Tankyrase (TNKS) belongs to multiple telomeric protein complexes and is actively involved in DNA damage repair. Although published research on TNKS indicates its possible role in cancer and other hypoxic diseases, its role in HA sicknesses remains elusive. Understanding the roles of telomeres, telomerase, and TNKS could ameliorate physiological issues experienced at HA. In addition, telomeric TNKS could be a potential biomarker in hypoxia-induced sicknesses or acclimatization. Thus, a new research avenue on TNKS linked to HA sickness might lead to the discovery of drugs for hypobaric hypoxia.
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