164P Effect of ELOVL5 expression on breast cancer development

Breast cancer is the most frequent cancer in women and the leading cause of women cancer death worldwide yet. A common feature of cancer cells is reprogramming of fatty acid metabolism which constitutes an adaptive mechanism but also a targetable weakness. We were interested in Elongate of very long chain fatty acid protein 5 (ELOVL5) which catalyzes the addition of two carbons to the chain of long-chain fatty acids. Indeed, the analysis of Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset showed a poor overall survival in breast cancer patients with low expression of ELOVL5.