Application of Latex particles in detecting alpha-fetoprotein(AFP)

Objective:To evaluate the application value of Latex method in detection of alpha-fetoprotein(AFP).Methods: Repetitive determination tests within and between batches were done on serum specimens,then the determination results were compared and analyzed by Latex method and electrochemiluminescence assay.Results: The results had no significant difference between Latex method and electrochemiluminescence assay,the recoveries were 95.5% for Latex method and 96.7% for electrochemiluminescence assay.Conclusion: Though electrochemiluminescence assay had high sensitivity and precision,it was not suitable for the wide use due to its high cost in instrument and reagent.Latex method had good correlation with electrochemiluminescence assay,which can be applied widely for its rapidness,stable results and low cost.