银屑病
TLR7型
医学
Toll样受体
受体
银屑病性关节炎
免疫学
TLR9型
下调和上调
癌症研究
免疫系统
先天免疫系统
生物
内科学
基因表达
DNA甲基化
基因
生物化学
作者
Farzaneh Rahmani,Nima Rezaei
标识
DOI:10.1080/1744666x.2016.1204232
摘要
Introduction: Expression of various Toll-like receptors (TLR) in keratinocytes (KCs) has offered new insights into the pathogenesis of psoriasis. When plasmacytoid dendritic cells (pDCs) are scarce in established psoriatic lesions, KCs take the responsibility to secrete IFN type 1 through TLR9 activation. Antagonists of TLR7 and TLR8 and anti-IL-12/IL-23 substances have shown promising results in treating psoriasis.Areas covered: References in this study were extracted from Scopus, PubMed and Embase databases by the search term: (‘Toll-Like Receptors’ OR ‘TLR’) AND (‘Psoriasis’ OR ‘Arthritis, Psoriatic’ OR ‘PsA’).Expert commentary: As the prevailing cell type, KCs play a major role in the maintenance of psoriatic lesions. By specific upregulation of IL-36 R, KCs can start the IL-23/IL-12 axis, leading to production of major culprits of psoriatic phenotype IL-17 and IL-22. Targeting IL-36 R could be considered as a new therapeutic target to eliminate cutaneous manifestations of psoriasis.
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