Curcumin has been reported to have many pharmacological activities,such as antioxidant,antitumor,and antibacterial activities.In recent years,a number of curcuminoids have been designed and synthesized to obtain more effective antioxidants.The antioxidant mechanisms of curcumin and its derivatives are discussed,and the research progresses in the synthesis of antioxidant curcuminoids are reviewed in this paper.