Establishment of all animal model with ureaplasma urealyticum:distribution of ureaplasma urealycum in urogenital system

One hundred male SD rats were divided into three groups:45 in group A,22 in group B and 33 in group C。 Each animal in group A were infected with ureaplasma urealyticum serotype 8 (T960)by injecting broth containing organisms(105CCU / ml)into the urinary bladder following laparotomy. Animals in group B were treated similarly in group A. After 3 month8,animals in group B were given minocin(20～100 mg / kg)for l4 days.As a control group animals in group C were injected with broth only.The results showed that ureaplasma urealyticum were detected from urinary bladders (87.5%),testes (62.5%),epididymis(55%),seminal vesicles(65%),and prostates(57.5%).The positive infection rate of ureaplasma urealyticum in group B is significantly lower than that in group A,while the animals in group C were all negative.