Pummer重排
类型(生物学)
化学
地质学
有机化学
古生物学
醋酸酐
催化作用
作者
David S. Grierson,Henri-Philippe Husson
出处
期刊:Elsevier eBooks
[Elsevier]
日期:1991-01-01
卷期号:: 909-947
被引量:25
标识
DOI:10.1016/b978-0-08-052349-1.00175-x
摘要
In 1927 the Polonovskis reported their discovery that treatment of a tertiary amine N-oxide with acetic anhydride or acetyl chloride results in a rearrangement in which one of the alkyl groups attached to nitrogen is cleaved and the N-acetyl derivative of the corresponding secondary amine and aldehyde are obtained (equation 1).1,2 Although originally considered to be a mild method for N-demethylation of tertiary amines, it is now recognized that the Polonovski reaction provides ready access to iminium ions, enamines, tertiary amides and/or secondary amines and aldehydes.3–6
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