高脂血症
阿托伐他汀
氧化应激
医学
SOD2
活性氧
听力损失
抗氧化剂
耳蜗
超氧化物歧化酶
内科学
内分泌学
药理学
听力学
糖尿病
化学
生物化学
作者
Yun Yeong Lee,Oak‐Sung Choo,Yeon Ju Kim,Eun Sol Gil,Jeong Hun Jang,Yup Kang,Yun‐Hoon Choung
标识
DOI:10.1016/j.bbamcr.2020.118850
摘要
It is known that hyperlipidemia is a risk factor for sensorineural hearing loss. However, the biological mechanisms underlying hyperlipidemia and hearing impairment have not been completely elucidated in the cochlea. Based on our previous study of human subjects, elderly people taking drugs for hyperlipidemia showed better hearing than those not taking any medications. We hypothesized that drugs for hyperlipidemia, such as statins, may have the potential to prevent hearing impairment. The aim of this study was to investigate the correlation between hyperlipidemia and hearing impairment and the hearing preservation effect of atorvastatin using a hyperlipidemic mouse model with diet-induced obesity (DIO). Here, we demonstrate that DIO mice had a significant hearing impairment as well as increased levels of reactive oxygen species (ROS) and hair cell death due to reduced levels of pAKT and superoxide dismutase 2 (SOD2). However, these changes were significantly prevented by atorvastatin. Oxidative stress-induced intrinsic apoptosis was decreased by the high expression of Nrf2 and antioxidant genes, which improved mitochondrial function and ROS via activation of the PI3K-pAKT pathway by atorvastatin. Therefore, atorvastatin has the potential to prevent hearing impairment via redox balance in the presence of hyperlipidemia.
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