金黄色葡萄球菌
化学
氯霉素
微生物学
抗生素
阿米卡星
膜透性
卡那霉素
抗菌活性
细菌细胞结构
细菌
生物化学
膜
生物
遗传学
作者
Chunyan Zhang,Liqiang Wang,Wei Deng,Haiyan Huang,Jintao Wang,Xiangwen Liao,Xuemin Duan,Ruilian Yu,Yan‐Shi Xiong
标识
DOI:10.1016/j.jinorgbio.2023.112385
摘要
Staphylococcus aureus (S. aureus), one of the Gram-positive bacteria, is easily to develop drug-resistance. Drug-resistant S. aureus infection leads to high morbidity and mortality. The complexes, namely [Ru(dpa)2(PSPIP)](PF6)2 (Ru1), [Ru(dpa)2(TSPIP)](PF6)2 (Ru2), and [Ru(dpa)2(TBPIP)](PF6)2 (Ru3), were synthesized using 2, 2′-dipyridylamine as an auxiliary ligand and three main ligands PSPIP, TSPIP, TBPIP. In vitro studies demonstrated that the Ru1–3 exhibited excellent antibacterial activity against S. aureus while showing low hemolytic toxicity to rabbit red blood cells. Notably, Ru3 was found to disrupt the bacterial cell membrane and alter its permeability through fluorescence staining and scanning electron microscopy (SEM) analysis. Furthermore, Ru3 displayed low toxicity in G. mellonella Larvae. To some extent, Ru3 inhibited biofilm formation on S. aureus as well as hemolytic toxin production, thereby attenuating the development of drug resistance without cross-resistance with other antibiotics. In addition, complex Ru3 exhibited a synergistic effect when combined with antibiotics such as amikacin, kanamycin, tobramycin and chloramphenicol, making it a valuable antibiotics adjuvant.
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