医学
植入
左心耳阻塞
队列
外科
闭塞
血栓
入射(几何)
心脏病学
内科学
心房颤动
华法林
物理
光学
作者
Pedro Cepas-Guillén,Eduardo Flores‐Umanzor,Nina Leduc,Vilhemas Bajoras,Nils Perrin,Julio I. Farjat‐Pasos,Angela McInerney,Ann LaFond,Xavier Millán,Sandra Zendjebil,Gilles O’Hara,Réda Ibrahim,Ole De Backer,Ignacio Cruz‐González,Dabit Arzamendi,Laura Sanchís,Philippe Garot,Jens Erik Nielsen‐Kudsk,Luis Nombela‐Franco,Adel Aminian,Josep Rodés‐Cabau,Xavier Freixa
标识
DOI:10.1016/j.jcin.2023.05.045
摘要
Device-related thrombus (DRT) remains one of the main concerns after left atrial appendage occlusion (LAAO). Several risk factors have been proposed, but most cannot be modulated. A modifiable factor such as device implantation depth is a potential target to adjust the risk for DRT. The aim of this study was to assess the impact of LAAO device implantation depth as a predisposing factor for DRT. The study included patients who underwent successful LAAO at 9 centers in Europe and Canada. Patients were classified into 2 groups: proximal device implantation (covered pulmonary ridge [PR] in the lobe and disc cohort or <5 mm from the PR in the single-lobe cohort) and distal device implantation (uncovered PR in the disc and lobe cohort and ≥5 mm in the single-lobe cohort). A total of 1,317 patients were included. Among these, proximal and distal device implantation was achieved in 732 (55%) and 585 (45%) patients, respectively. No differences in procedural outcomes were observed between the groups. At follow-up, patients with proximal implantation had a lower incidence of DRT (2.3%) than those with distal implantation (12.2%) (P < 0.001). Deeper device implantation and a larger uncovered left atrial appendage area were associated with a higher incidence of DRT (P < 0.001), regardless of device type. In multivariable analysis, distal implant (HR: 5.92; 95% CI: 3.39-10.36) and no or single antiplatelet therapy (HR: 1.62; 95% CI: 0.99-2.62) emerged as independent predictors of DRT. LAAO device implantation depth is an independent risk factor for DRT. Deeper device implantation and larger uncovered left atrial appendage areas were associated with a higher incidence of DRT.
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