铕
泌尿系统
纳米探针
生物标志物
体内
光致发光
镧系元素
尿
肾脏疾病
纳米技术
医学
化学
材料科学
发光
内科学
纳米颗粒
生物
生物化学
离子
生物技术
光电子学
有机化学
作者
Xiaorong Song,Mei Li,Siqi Ni,Kaidong Yang,Shihua Li,Renfu Li,Wei Zheng,Datao Tu,Xueyuan Chen,Huanghao Yang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-02-22
卷期号:23 (5): 1878-1887
标识
DOI:10.1021/acs.nanolett.2c04849
摘要
Urinary sensing of synthetic biomarkers that are released into urine after specific activation in an in vivo disease environment is an emerging diagnosis strategy to overcome the insensitivity of a previous biomarker assay. However, it remains a great challenge to achieve sensitive and a specific urinary photoluminescence (PL) diagnosis. Herein, we report a novel urinary time-resolved PL (TRPL) diagnosis strategy by exploiting europium complexes of diethylenetriaminepentaacetic acid (Eu-DTPA) as synthetic biomarkers and designing the activatable nanoprobes. Notably, TRPL of Eu-DTPA in the enhancer can eliminate the urinary background PL for ultrasensitive detection. We achieved sensitive urinary TRPL diagnosis of mice kidney and liver injuries by using simple Eu-DTPA and Eu-DTPA-integrated nanoprobes, respectively, which cannot be realized by traditional blood assays. This work demonstrates the exploration of lanthanide nanoprobes for in vivo disease-activated urinary TRPL diagnosis for the first time, which might advance the noninvasive diagnosis of diverse diseases via tailorable nanoprobe designs.
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