红斑狼疮
系统性红斑狼疮
盘状红斑狼疮
CD8型
电池类型
细胞
免疫学
成纤维细胞
医学
生物
病理
免疫系统
细胞培养
抗体
遗传学
疾病
作者
Meiling Zheng,Zhiyan Hu,Xiaole Mei,Lianlian Ouyang,Yang Song,Wenhui Zhou,Yi Kong,Ruifang Wu,S. Rao,Hai Long,Wei Shi,Hui Jing,Shuang Lu,Haijing Wu,Sujie Jia,Qianjin Lu,Ming Zhao
标识
DOI:10.1038/s41467-022-35209-1
摘要
Abstract Discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) are both types of lupus, yet the characteristics, and differences between them are not fully understood. Here we show single-cell RNA sequencing data of cutaneous lesions from DLE and SLE patients and skin tissues from healthy controls (HCs). We find significantly higher proportions of T cells, B cells and NK cells in DLE than in SLE. Expanded CCL20 + keratinocyte, CXCL1 + fibroblast, ISG hi CD4/CD8 T cell, ISG hi plasma cell, pDC, and NK subclusters are identified in DLE and SLE compared to HC. In addition, we observe higher cell communication scores between cell types such as fibroblasts and macrophage/dendritic cells in cutaneous lesions of DLE and SLE compared to HC. In summary, we clarify the heterogeneous characteristics in cutaneous lesions between DLE and SLE, and discover some specific cell subtypes and ligand-receptor pairs that indicate possible therapeutic targets of lupus erythematosus.
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